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    Savanah Tujague
    Nov 19, 2025, 03:00
    Updated at: Nov 19, 2025, 03:00

    San Francisco's star-studded offense, finally whole, aims to dominate a struggling Panthers squad searching for a breakthrough win.

    The San Francisco 49ers return home under the lights this Monday night, looking to build momentum after a strong Week 11 victory. Their opponent: the Carolina Panthers, a young, rebuilding team searching for stability and a statement win. It’s a cross conference matchup and a chance for San Francisco to break their even week losing curse. 

    49ers Enter With Renewed Stability on Offense

    For the first time since Week 1, the 49ers finally had Brock Purdy, Christian McCaffrey, George Kittle, and Ricky Pearsall all on the field together last week and the results showed. Purdy, back from a turf toe injury, looked sharp and comfortable in his return, throwing three touchdowns and showing why Kyle Shanahan never wavered on him being the team’s QB1.

    With Purdy healthy, the run game humming behind McCaffrey, and Kittle coming off one of his best all-around performances of the season, the 49ers enter this matchup with their full offensive identity restored. The Panthers defense has talent, especially in the secondary, but their inconsistency in stopping the run has been a major issue, and McCaffrey could be in line for a heavy impact game against his former team.

    Carolina Searching for Answers

    The Panthers’ season has been a mix of flashes and frustration. They have young talent, but injuries, inexperience, and offensive inconsistency have held them back. Whether Carolina can keep pace will depend heavily on its ability to generate explosive plays and avoid long third down situations.

    Their defense, anchored by Jaycee Horn and Derrick Brown, has shown moments of potential but has also struggled against elite offenses. On the road, in prime time, against a fully healthy 49ers unit, a three hour time difference away, Carolina will need to play its most disciplined games of the season.

    Key Matchups to Watch

    Christian McCaffrey vs. Panthers Front Seven

    McCaffrey always draws attention but especially when facing his former team. Carolina’s run defense has been vulnerable, and allowing CMC to set the tone could put the Panthers on their heels early.

    Brock Purdy vs. Carolina’s Secondary

    The Panthers’ defensive backs are talented and aggressive. Purdy’s timing and decision making will be tested, especially on intermediate routes.

    Panthers Offense vs. 49ers Pass Rush

    San Francisco’s defense forced three turnovers last week and appears to be regaining its opportunistic identity. If the Panthers fall behind early, protecting the quarterback becomes a major concern.

    What’s at Stake

    San Francisco is fighting to stay in the thick of the NFC playoff race, and stacking wins is crucial with a tough December stretch ahead. Carolina, meanwhile, is searching for progress.

    If the 49ers’ stars stay in sync the way they were last week, they’ll be in a strong position to control the game from start to finish.