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McCaffrey Limited at Practice as Illness Emerges Ahead of Titans Matchup cover image
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Alec Elijah
Dec 12, 2025
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Should the 49ers be worried about Christian McCaffrey logging a limited practice on Thursday?

The San Francisco 49ers received an unexpected development on Thursday as star running back Christian McCaffrey was listed as limited in practice due to an illness, according to David Lombardi of SFStandard.com.

While midweek setbacks are not uncommon late in the season, any change involving McCaffrey instantly becomes headline-worthy given his central role in the 49ers’ offense.

McCaffrey has been one of the NFL’s most productive and durable players this season, ranking fifth in the league with 85 receptions and third with 237 carries through 13 games.

His 1,655 yards from scrimmage and 13 total touchdowns place him firmly in the MVP conversation and highlight just how much the 49ers depend on him as both a runner and a receiver.

With San Francisco gearing up for a critical Week 15 matchup against the Tennessee Titans, even a minor disruption invites attention.

Reporters on hand during the media-viewing portion of Thursday’s session—typically 10 to 20 minutes, mainly consisting of stretching and individual drills helped confirm that McCaffrey was present but limited.

After participating briefly, he appeared to scale back his involvement. The Athletic’s Matt Barrows added that McCaffrey “didn’t look terrific in the locker room after practice,” further underscoring that the illness was noticeable.

Despite this, there is no immediate indication that McCaffrey is in danger of missing Sunday’s game.

The 49ers have historically shown caution with their key players, and with McCaffrey serving as the offense’s workhorse, there is little incentive to push him through non-essential practice reps when he’s under the weather.

At this stage of the week, rest may be as valuable as anything he could accomplish on the field.

The real concern isn’t Thursday’s limitation, but whether the illness lingers into the weekend and affects his conditioning or game-day effectiveness.

McCaffrey’s workload and impact are such that even a partial drop-off can shift the complexion of the 49ers’ offensive rhythm.

Friday’s participation report should offer a clearer picture of his trajectory and whether he’s trending toward a full recovery.

If McCaffrey cannot shoulder his typical load, Brian Robinson, who is next in line in San Francisco’s backfield, would likely see an expanded role.

While Robinson is capable, no one replicates McCaffrey’s versatility or gravitational pull on opposing defenses.

For now, the 49ers will hope their star back uses the next couple of days to shake off the illness.

With Sunday approaching and playoff positioning on the line, ensuring McCaffrey is at full strength remains a top priority for San Francisco.