Even in Vatican City, the Crosstown Rivalry lives on — and this time, the South Side is the one laughing.

Noted Chicago White Sox fan Pope Leo XIV — perhaps the most powerful South Sider on Earth — is back in the headlines, and naturally, it involves taking a swipe at the Chicago Cubs.

A video that surfaced online Wednesday shows The Pope himself riding through a crowd at the Vatican, waving to the people. That’s when it happened. A voice from the crowd, full of Midwestern mischief, yelled out: “Go Cubs!”

Without missing a beat, Pope Leo XIV turned to his right, processed what was said… and hit back with the kind of delivery that would make any Sox fan proud.

“¡Han perdido! They lost!” he fired back, with the tone of a man who has been waiting his entire papal reign for this exact moment.

And just like that, the Crosstown Cup has officially gone global. Forget Wrigley and Guaranteed Rate — the rivalry just entered Vatican City.

Th South Side Pope

For those who haven’t been following the legend, Pope Leo XIV — born Robert Francis Prevost — has been affectionately adopted by White Sox fans after multiple public nods to the team. Whether he's receiving Sox gear, casually mentioning Chicago, or now openly dunking on the Cubs, Leo has taken on a the persona of The Patron Saint of South Side Spite.

White Sox Twitter wasted no time. Within minutes, the clip was everywhere. Edits rolled in: Leo XIV photoshopped in a vintage Paul Konerko jersey under his vestments. All the memes you could imagine Someone even mock-up’d a Vatican flag with the Sox logo stitched next to the crossed keys.

Mind you, there's a reason this man has a mural in the concourse of Rate Field.

Meanwhile, Cubs fans — used to national pundits, broadcasters, and even late-night hosts clowning them — had to sit with perhaps the most surreal blow yet: They just got roasted by the Pope.

Only in Chicago could a papal blessing turn into a baseball jab. This city thrives on rivalry. It’s not enough for one team to win — the other has to feel it. And deep down, every Sox fan knows this: the on-field product in recent years hasn't given them the opportunity to have bragging rights for quite some time. 

Pope Leo XIV just cemented himself in Crosstown history.