The Seattle Mariners suffered arguably their most disappointing loss of the season in a 7-6 defeat at the hands of the San Diego Padres on Wednesday at Petco Park in Seattle.

The Mariners (8-11) had control nearly the entire game before allowing five runs to the Padres in the ninth inning. The loss gave San Diego a 2-0 record and a series win in this year's Eddie Vedder Cup Series.

Seattle has had three road series this season and has lost all of them after Wednesday's collapse.

Here's several takeaways from the Mariners' ninth-inning meltdown against the Padres:

The ninth inning collapse was a series of unfortunate events that led to an awful conclusion for Seattle.

For San Diego, it was center fielder Jackson Merrill that delivered the death knell. He hit a walk-off, two-RBI double that went to the left field corner that clinched the win for the Padres.

Merrill finished the game 2-for-5 with a run and two RBIs. He also robbed a potential two-run home run from Seattle's own center fielder, Julio Rodriguez, in the top of the third.

The Mariners were unable to score in that inning. Considering how the game ended, that robbed homer was likely just as important as the walk-off double.

For the second-straight outing, Seattle two-time All-Star closer Andres Munoz struggles to close out the game.

In Munoz's last appearance against the Houston Astros on April 11, he allowed one hit and walked two batters and had to get out of a bases-loaded situation in a tied all game.

Munoz was able to do just that but didn't have the same luck against the Padres.

The two-time All-Star entered the game after a four-day layoff working with a 6-2 lead. He gave up a lead-off walk to Manny Machado after a seven-pitch plate appearance and allowed a double to Gavin Sheets, giving San Diego two runners in scoring position and no outs.

Munoz struck out Nick Castellandos before allowing a single to Ty France, an RBI sacrifice fly hit by Fernando Tatis Jr. and an RBI single hit by catcher Luis Campusano, cutting the Mariners' lead to 6-4.

After Munoz allowed an RBI single to Ramon Laureano, Munoz was taken out of the game for Jose Ferrer, who ultimately allowed the game-winning hit to Merrill.

Munoz finished his outing with one strikeout, one walk and five earned runs allowed on four hits in 0.2 innings pitched. His ERA ballooned from 3.00 to 9.45.

Munoz has earned trust from the Mariners for his multiple years as an elite closer but his last two outings can't be ignored.

One thing that will likely be overlooked considering how the game ended was the fact that Wednesday's contest was the best combination of stellar starting pitching and offense from Seattle in a road game.

Mariners starting pitcher Emerson Hancock had his third quality start in four outings Wednesday. He struck out six batters, walked one and allowed two earned runs on four hits (one home run) in six innings pitched.

The offense scored six runs on 10 hits and drew seven walks. Luke Raley, Cal Raleigh, Randy Arozarena and Dominic Canzone all had extra-base hits. Raley connected for a two-run homer in the top of the fifth.

Seattle's offense wasn't perfect. It left a lot of potential runs on the table. It went 3-for-16 with runners in scoring position and stranded 11 runners on base. The Padres went 4-for-10 with runners in scoring position and left five on base, for comparison.

It will likely be hard for the Mariners to take any solace in a defeat the nature of Wednesday's, but the offense bouncing back from a one-run game the previous night is a good sign.

Seattle will look to salvage a game against San Diego in the series finale at 5:40 p.m. PT on Thursday.

Luis Castillo will start for the Mariners and Walker Buehler will start for the Padres.

Remember to join our MARINERS on ROUNDTABLE community, which is FREE! You can post your own thoughts, in text or video form, and you can engage with our Roundtable staff, as well as other Mariners fans. If prompted to download the Roundtable APP, that's free too!