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The New York Knicks open up their 2025-2026 NBA regular season against the Cleveland Cavaliers on Wednesday. The game will start at 7 pm ET from Madison Square Garden.

The Mike Brown Era will begin Wednesday night as the New York Knicks open their season against the Cleveland Cavaliers at Madison Square Garden. Brown makes his coaching debut with the Knicks as he takes over from Tom Thibodeau, who was let go at the end of the postseason.

Here is everything to know before the Knicks face the Cavaliers Wednesday night.

How to Watch New York Knicks vs. Cleveland Cavaliers

Who:  Cleveland Cavaliers vs. New York Knicks

When:  Wednesday, Oct. 22 at 7 p.m. ET

Where:  Madison Square Garden, New York

TV:  MSG, ESPN

Announcers: ESPN: Mike Breen (Play-by-Play), Tim Legler, Richard Jefferson (Analysts), Lisa Salters (Sideline Reporter).

Radio: ESPN New York 880 and 95.7 FM

Radio Announcers: Tyler Murray (Play-by-Play), Monica McNutt (Color Commentator/Analyst)

Point Spread: The Cleveland Cavaliers are 1.5 point favorites and the over/under is set at 227.5, according to DraftKings Sports Book.

Records:  This is the season-opening game for both teams.

Series History:  The teams have played 230 total regular season games. The Knicks lead the series 121-109.

Injuries: Knicks - Mitchell Robinson (out, ankle), Josh Hart (out, back spasms), Karl-Anthony Towns (questionable), OG Anunoby (probable). Cavaliers - Darius Garland (out, toe injury), Max Strus (out, foot injury), De'Andre Hunter (questionable, knee)