Northwestern vs. Michigan State: How to Watch, Betting Odds and Injury Report

Northwestern travels to East Lansing to face Michigan State in a Big Ten matchup filled with intriguing storylines. Here's everything to know about Saturday's kickoff, streaming coverage, betting odds and injuries.

Northwestern hits the road Saturday for a Big Ten showdown against Michigan State, looking to continue its impressive start to the 2026 season.

The No. 25 Wildcats enter the matchup with a 4-1 record after dominating Ball State 45-14 at New Ryan Field. Northwestern has won four of its first five games, with its only loss coming against Indiana on the road.

Saturday's matchup will be particularly meaningful for Chiles, who spent two seasons at Michigan State before transferring to Northwestern. He will now return to Spartan Stadium looking to lead the Wildcats to their first road victory of the season.

Another major storyline will be the coaching matchup between Northwestern head coach David Braun and former Wildcats head coach Pat Fitzgerald, who now leads Michigan State.

Both teams are also dealing with significant injury concerns heading into Saturday, making player availability an important factor to monitor before kickoff.

Northwestern enters as the road favorite, but with the Spartans looking to turn their season around, the Wildcats cannot afford to overlook this matchup as they look to get their first road victory.

Here's everything you need to know before Northwestern faces Michigan State on Saturday.

Northwestern Wildcats (4-1) @ Michigan State Spartans (2-4)

Location: Spartan Stadium | East Lansing, Michigan

Date: Saturday, Oct. 17

Time: 11 a.m. CT / Noon ET

Streaming: Peacock

TV: No traditional television broadcast; Peacock exclusive

Radio: WGN 720 AM

Current Key Lines (BetMGM Sportsbook)

Spread: Northwestern -7.5, Michigan State +7.5

Over/Under: 49.5

Moneyline: Northwestern -315, Michigan State +250

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Northwestern Wildcats:

#6 Robert Fitzgerald

#13 Josh Fussell

#22 Daniel Anderson

#37 Max Mohring

#40 Jason Reynolds II

#44 Callen Campbell

#50 Qayvier Johnson

#61 David Anchondo

#62 Ezomo Oratokhai

#79 Jacob Miller

#81 Chris Petrucci

#84 Luke Dehnicke

Michigan State Spartans:

#0 Cam Edwards

#2 Cam Fancher

#3 Tre Bell

#4 Charles Brantley

#5 Jordan Hall

#20 Keshawn Williams

#22 Tyran Chappell

#27 Darrian Jones Jr.

#44 Jay Coyne

#45 Brady Pretzlaff

#75 Ben Murawski

#79 Tristan Comer

#87 Joe Caudill

QUESTIONABLE:

#19 Charles Taplin