TCU's defense has been one of the Horned Frogs' biggest strengths this season. Friday night, that unit will face a quarterback capable of putting up video-game numbers.

The Horned Frogs (4-4) travel to Tucson to face No. 24 Arizona (6-2) in a Big 12 matchup featuring two teams moving in different directions.

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Arizona is coming off a 34-26 loss to Texas Tech, but the Wildcats' passing attack remains dangerous. Quarterback Noah Fifita threw for 417 yards in that defeat, and TCU will need to be ready for another aggressive aerial assault.

Here are five Arizona offensive players that will deserve attention Friday night.

Fifita is easily the biggest threat.

The fifth-year senior has completed 74.1 percent of his passes for 2,481 yards, 19 touchdowns and just four interceptions.

Against Texas Tech, he completed 33 of 45 attempts for 417 yards and a touchdown without throwing an interception.

Fifita is also Arizona's career leader in passing yards and touchdown passes. His experience, accuracy and quick decision-making make him difficult to pressure.

TCU must disrupt his timing rather than allowing him to operate comfortably from the pocket.

Mizell is Arizona's most explosive offensive weapon.

The junior has caught 34 passes for 675 yards and six touchdowns, averaging an impressive 19.9 yards per reception.

He torched Texas Tech for 182 yards and a touchdown on seven receptions last Saturday.

Mizell's ability to stretch the field makes him particularly dangerous against aggressive defensive schemes. One missed assignment could become a 60-yard touchdown.

Richardson gives Fifita another dependable target.

Despite appearing in only four games, Richardson has collected 22 receptions for 277 yards.

His return to Arizona's receiving rotation has provided an important boost, particularly with other Wildcats dealing with injuries.

Richardson's ability to find openings underneath coverage could create problems if TCU devotes additional defenders to Mizell.

Phelps has quietly become another productive option.

Through eight games, he has caught 21 passes for 280 yards and three touchdowns.

His 13.3 yards per reception demonstrate that Arizona doesn't have to rely exclusively on Mizell to produce meaningful gains.

TCU's secondary must remain disciplined when Fifita begins spreading the football around.

While Arizona's passing game receives most of the attention, the Ole Miss transfer remains a significant threat near the goal line.

He leads the Wildcats with 321 rushing yards and seven rushing touchdowns on 89 carries.

Against Texas Tech, Reescano managed just 18 yards on nine attempts, but scored twice.

The Red Raiders held Arizona to only 12 rushing yards as a team, exposing a weakness TCU should attempt to exploit.

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The Wildcats are also dealing with injuries at receiver. Tre Spivey, who has 314 receiving yards and four touchdowns, is expected to miss the remainder of the season with a foot injury. R.J. Mosley is also sidelined.

TCU's defense enters allowing just 14.1 points and 113 rushing yards per game. The Horned Frogs have also held opponents to a 31.4 percent conversion rate on third down.

Those numbers suggest TCU has the personnel to make Arizona uncomfortable.

But the key will be preventing Fifita from connecting with Mizell for explosive plays while limiting Reescano's opportunities in short-yardage situations.

Make Arizona one-dimensional, pressure Fifita and force turnovers.

That's the formula for TCU to pull off a ranked road upset Friday night.