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Trent Williams’ Injury Clouds 49ers’ Night and Future cover image
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Alec Elijah
Dec 29, 2025
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Several questions begin to arise as the 49ers' starting tackle, Trent Williams, exits Monday's game with an injury.

The San Francisco 49ers could not have imagined a worse way to begin their Sunday night showdown.

On the very first snap, quarterback Brock Purdy’s pass was intercepted and returned for a touchdown, instantly swinging momentum.

As the play unfolded, an even more troubling development followed: veteran left tackle Trent Williams went down with a right hamstring injury while desperately trying to chase Bears linebacker T.J. Edwards into the end zone.

Williams immediately grabbed at his leg and limped off the field, heading straight to the blue medical tent for evaluation.

He remained there for approximately 11 minutes before reemerging without his helmet, walking cautiously toward the bench.

Although the team initially listed him as questionable to return, the visual signs were discouraging. Shortly after, Williams was replaced by Austen Pleasants and did not see the field again.

By halftime, San Francisco officially ruled him out.

The loss of Williams is significant for any game, but especially for a team with postseason ambitions.

At 37 years old, Williams remains one of the NFL’s premier offensive linemen and a vital piece of the 49ers’ offensive identity.

Recently selected to his 12th Pro Bowl, he is tied for the second-most Pro Bowl appearances by an offensive lineman in league history.

His leadership, experience, and ability to dominate the line of scrimmage are difficult, if not impossible, to replicate.

Interestingly, Williams had appeared on the practice report earlier in the week.

He missed sessions on Wednesday and Thursday before participating in a limited practice on Friday.

The team described those absences as rest-related rather than injury-related, but Sunday night’s events may prompt closer scrutiny of that explanation.

Despite losing their star left tackle almost immediately, the 49ers showed resilience.

San Francisco managed to score four offensive touchdowns in the first half without Williams, leaning on quick decision-making from Purdy and strong performances from the skill-position players.

Still, the absence of their blindside protector was noticeable, particularly in pass protection adjustments and the overall flow of the offense.

Beyond the immediate impact on Sunday night’s game, Williams’ injury raises larger concerns.

The 49ers are approaching a critical point in their season, with a Week 18 matchup against the Seattle Seahawks looming.

That game could determine the division title, and any lingering hamstring issue could jeopardize Williams’ availability not only for that contest but also for the playoffs.

Williams had managed to start every game this season after missing time in each of the previous nine years due to injury.

That durability made his sudden exit all the more deflating. For now, San Francisco must wait for further updates and hope the injury proves minor.

As the team pushes toward the postseason, the health of Trent Williams may ultimately shape how far the 49ers can go.