Nov 13, 2026 1:00 PM
San Francisco’s offense gains momentum as Deebo Samuel nears a return, but a depleted secondary and new injuries to Trent Williams and Dre Greenlaw threaten the defense.
With Sunday’s Week 10 road showdown against the Dallas Cowboys fast approaching, the San Francisco 49ers’ Thursday injury report brought mounting alarm in the defensive backfield, alongside new injury designations for two of the team’s most indispensable veterans.
Secondary Crisis: Lenoir and Green Miss Second Straight Day
San Francisco’s top two outside cornerbacks, Deommodore Lenoir (foot) and Renardo Green (back), both sat out Thursday’s session after missing Wednesday’s practice. With only Friday’s final walkthrough remaining before the team departs for Arlington, Texas, the availability of both starters is squarely in jeopardy.
To compound matters in the secondary:
- Upton Stout (CB – Shoulder / Neck): The starting nickel corner remained limited and practiced in a blue non-contact jersey, signaling that he is still protecting upper-body soreness.
- Siran Neal (S – Knee / Foot): Logged a second consecutive limited session.
- Depth Chart Crunch: If Lenoir and Green cannot suit up, San Francisco’s healthy cornerback depth shrinks to Nate Hobbs (who practiced in full on Thursday after working back from an adductor injury), rookie Ephesians Prysock, Siran Neal, and practice-squad veteran Jack Jones.
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New Injury Designations for Williams and Greenlaw
Left tackle Trent Williams and linebacker Dre Greenlaw both sat out Wednesday’s practice for routine veteran maintenance. When the duo returned to the field in a limited capacity on Thursday, both were attached to actual physical ailments: Williams with a shoulder injury and Greenlaw with a knee issue.
Losing Williams would create a massive void on Brock Purdy’s blindside against a Dallas pass rush, while Greenlaw is the tone-setter in the middle of Raheem Morris’ defense. Friday’s practice participation and final game-status designations will be critical indicators for both All-Pros.
Offensive Silver Lining: Deebo Samuel Trending Toward Return
On the offensive side of the ball, Deebo Samuel logged back-to-back limited practices as he works back from a hamstring strain that sidelined him for the past three contests. His steady progression indicates he is on track to return against Dallas, giving Kyle Shanahan a vital playmaker alongside newly acquired wide receiver Keenan Allen and healthy starter Demarcus Robinson (full participant, ankle).
Meanwhile, veteran wideout Mike Evans missed his second straight day with Achilles tendinitis and appears to be missing another game as San Francisco takes a cautious approach with his recovery.
Complete Thursday Practice Report (49ers vs. Cowboys)
| Player | Position | Injury | Wed. Status | Thu. Status |
| Deommodore Lenoir | CB | Foot | DNP | DNP |
| Renardo Green | CB | Back | DNP | DNP |
| Mike Evans | WR | Achilles | DNP | DNP |
| Trent Williams | OT | Shoulder (Wed: Rest) | DNP | Limited |
| Dre Greenlaw | LB | Knee (Wed: Rest) | DNP | Limited |
| Deebo Samuel | WR | Hamstring | Limited | Limited |
| Upton Stout | CB | Shoulder / Neck (Non-Contact) | Limited | Limited |
| Siran Neal | S | Knee / Foot | Limited | Limited |
| C.J. West | DT | Knee (21-Day IR Window) | Limited | Limited |
| Christian McCaffrey | RB | Rest | DNP | Full |
| Demarcus Robinson | WR | Ankle | Full | Full |
| Nate Hobbs | CB | Adductor | Full | Full |
Friday’s final practice session will be decisive for San Francisco’s game plan heading into Dallas. All eyes will be on whether Deommodore Lenoir and Renardo Green can get back on the grass in any capacity, as well as whether Trent Williams and Dre Greenlaw are cleared without restrictive game designations. If the secondary remains shorthanded, defensive coordinator Raheem Morris will have to lean heavily on his front seven to generate pressure and insulate a patchwork cornerback room against Dak Prescott and the Cowboys' passing attack.
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