

The San Francisco 49ers and Los Angeles Rams are set for another NFC West battle, and this time around, both defenses will be under the microscope. San Francisco’s unit has been hit with injuries but continues to find new contributors ready to step up, while the Rams’ young core on defense has shown flashes of real promise. As both sides look to set the tone physically, here are the defensive players to watch in this rematch.
Kevin Givens has been asked to do more with so many key starters sidelined, and he’s delivered. Nobody needs him to be Mykel Williams (who is now out for the season with an ACL tear), he just needs to be the best version of him. If he can disrupt Matthew Stafford’s pocket and limit Kyren Williams between the tackles, San Francisco’s defense can dictate the flow of the game early.
The rookie linebacker is starting to come into his own. Dee Winters’ has shown he can fly sideline-to-sideline and deliver big hits in space. Against a Rams offense that thrives on motion, Winters’ ability to diagnose plays quickly will be crucial in preventing chunk gains. His continued growth could make him a difference maker in this matchup.
Another rookie on the rise, Renardo Green brings energy and physicality to the 49ers’ secondary. With Puka Nacua playing through rib injuries, Green’s discipline in coverage and ability to tackle in open space will be tested. His confidence has been noticeable, and the Niners will count on him to hold his own in one-on-one matchups.
Rookie safety Kamren Kinchens has quickly made an impression with his instincts and ball- hawk ability. His range in coverage gives the Rams flexibility on the back end, especially against a 49ers offense that loves to attack the middle of the field. Kinchens’ ability to read Mac Jones’ eyes and close on crossing routes could be a deciding factor in limiting San Francisco’s pass game.
Byron Young continues to be one of the Rams’ most disruptive defenders off the edge. His burst and relentless motor make him a problem for opposing tackles. He’ll be hunting Mac Jones all afternoon. Young’s ability to set the edge against the run while still getting after the quarterback could determine whether Los Angeles can slow down the 49ers or not.
The 49ers’ defensive youth movement is starting to take shape, with Givens, Winters, and Green showing they’re ready to shoulder these bigger roles. On the other side, the Rams’ young duo of Kinchens and Young adds energy to a defense that refuses to quit. This game could come down to which group of emerging playmakers steps up when it matters most.