Oct 14, 2026 2:11 PM

Fresh off an impressive Monday night victory, the high-flying Bills bring the league's top-scoring offense to the desert to face a struggling Raiders squad in a projected shootout.

The Buffalo Bills continue their two-game West Coast trip this week with a game in the Mojave Desert against the Las Vegas Raiders. And after a stunning win over the Los Angeles Rams on Monday night, Buffalo heads into Week 6 in a familiar spot as favorites to win the game.

The Bills head into the game with a 4-1 record and sit atop the AFC East. The Raiders, on the other hand, are 3-2 but losers of two straight. They're also coming off a 45-17 blowout loss to the New England Patriots in Week 5. 

With the two teams going in a different direction right now, oddsmakers seem to trust Buffalo more than they do Las Vegas. And the numbers show that.

As of writing, Buffalo is a 5.5-point favorite over the Raiders. On the moneyline, the Bills are -245 favorites, while Las Vegas is +200 as the underdog. For those who don't follow betting much, that means you'd have to bet $245 to win $100 if the Bills win. 

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The sportsbooks also expect this game to be a shootout. The point total currently sits at 53.5, which is the highest in the NFL for Week 6. The closest game to that total is the Dallas Cowboys against the Green Bay Packers at 52.5. 

With the point total being 53.5 and the spread at 5.5, oddsmakers think the game will play out as a 30-24 win for Buffalo if everything hits. Of course, that's not a guarantee, and that's why they play the game.

Buffalo has one of, if not the, best offenses in football. They are averaging 32.8 points per game, which is tied with Detroit for the best in the league. The Bills also average 396.2 yards per game, good for 4th.

On the other side of things, the defense has been one of the worst units in the league. Giving up 388.6 yards and 28.2 points per game, the unit is in the bottom five of the NFL. Against a team that includes the likes of Brock Bowers and Ashton Jeanty on offense, it could be another long day at the office for that side of the ball.

The Bills and Raiders kickoff Sunday at 4:25pm ET on CBS Sports.

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