Jacksonville Jaguars at Indianapolis Colts Betting Preview (December 28, 2025)

NFL awards season is right around the corner.

Jacksonville Jaguars quarterback Trevor Lawrence, around +3500-5000 to win the league’s MVP award as per BetMGM, is on quite a late-season run for the AFC’s current No.3 seed 

Lawrence, who has thrown 12 touchdowns passes and zero interceptions in his last four games, has taken advantage of a solid running game to create big passing plays, even if most of them have come against the New York Jets, Indianapolis Colts and Tennessee Titans.

This is a big reason why the Jaguars are averaging 33 points a game since their bye week.

Liam Coen, Lawrence’s head coach, is +650, just behind Kyle Shanahan and Mike MacDonald, to win the NFL’s Coach of the Year, as per current BetMGM odds. 

First, the road favorite Jaguars (11-4) visit the Colts (8-7) for a 1:00 p.m. (ET) Sunday kickoff at Lucas Oil Stadium in Indianapolis. 

Jacksonville (-6.5, -110) 5-2 on the road this season, is -330 on the money line, while the Colts, coming off a 48-27 blowout loss to the San Francisco 49ers on Monday Night Football, are listed at +265. 

Indianapolis has lost five straight games and with Houston's Saturday win over the Los Angeles Chargers, find themselves on the outside of the playoff bracket and looking in. Their season will officially end next week.

The over/under total for the Fox Sports broadcast is 48.5. 

Jacksonville, coming off a 34-20 road win as an underdog vs. the AFC’s top-seeded Denver Broncos, are 5-2 on the road this season, have won three straight road games.

Lawrence threw for 279 yards and three touchdowns vs. the Broncos. 

The Colts, despite their recent struggles, are 6-2 at home thus far. 

Earlier this month, the Jaguars, a short home underdog at kickoff, defeated the Colts 36-19 in a crucial AFC South showdown at EverBank Stadium in Jacksonville.

Lawrence threw for 244 yards with two touchdowns in a win that allowed the undervalued Jags, who are 10-5 against the spread this season, to wrestle control away of the division from the Colts.

Jacksonville running back Travis Etienne had 74 yards rushing with two touchdowns. 

Lawrence, while careful with the football in recent weeks, is prone to putting it on the ground and the Colts defense has recorded 10 fumbles on the season, in addition to 36 sacks. 

Jacksonville has recorded 34 sacks and six INTs.

The Jaguars placed CB Jourdan Lewis (foot) on injured reserve earlier this week, and CB Greg Newsome III (shoulder), CB Montaric Brown (neck) and RB Byahshul Tuten (finger) have been limited in practice in recent days. Tuten was ruled out Saturday morning.

Colts CB Sauce Gardner (calf) is progressing well, and is likely to play against the Jaguars. 

The Jags are spotting the Colts less than a touchdown right now?

The ‘Phillip Rivers Traveling Show’, which had gimmick written all over from the very start, feels like a marketing ploy to sell tickets during the holidays for a team with dwindling playoff hopes.

Meanwhile, the Jaguars, 6-0 against the spread their last six times out, including three wins as an underdog, are giving off serious ‘Super Bowl contender’ vibes right now.

The Colts running game was AWOL vs. the 49ers on Monday night and the Jags defensive front is no joke. So, that spell trouble for Rivers and Co.

Indy was blown out by San Francisco, in a game in which the 49ers covered the 46.5 over/under total by themselves.

The Jaguars, 6-2 to the over in their last eight games, have been on a scoring binge as of late, averaging 33 points a game since their bye week. This includes 30-plus in their last three games.