Forget the fact that the Jacksonville Jaguars are coming off a more-lucky-than good, 27-24 OT road win over the Arizona Cardinals almost seven days ago.

Not only do the Jaguars currently hold the No. 6 seed in their conference, but they still have a legitimate shot at overtaking the Indianapolis Colts to win the AFC South title.

Enter the Jacksonville Jaguars (7-4), visiting the Tennessee Titans (1-10) at Nissan Stadium in Nashville for a Week 13 divisional game in the 1 p.m (kickoff) window on CBS/NFL Sunday Ticket.

Jacksonville, 6-4-1 against the spread this season and in search of a second straight road game, is currently a (-6.5, -110) point road favorite on the betting line and (-310) on the money line.

The Titans, looking to snap a six-game losing streak, which includes a 30-24 loss in Seattle last Sunday afternoon, have lost 10 straight games inside the ‘car shop’ and are 1-5 in their six previous meetings vs. the Jaguars.

One more home loss for the Titans, currently operating under interim head coach Mike McCoy, would match the franchise’s longest home-losing skid since moving to Tennessee.

The Jaguars, in a prime spot to not only strengthen their positioning in the AFC playoff picture, but stay in plain view of the Colts, host Indianapolis on Sunday, Dec. 7.

But the Jaguars, 3-2 on the road this season, would be smart not to plan ahead, given they’ve needed OT sessions on the road in recent weeks to get by the Cardinals and Las Vegas Raiders, respectively.

With the defense, despite getting two sacks from Derrick Gardeck, who was playing against his former team, struggling in stretches of the game to stop Cardinals QB Jacoby Brissett from creating big plays in the passing game.

Better play in the secondary is of the essence moving forward, given the Jaguars, for all their apparent flaws, are a legitimate playoff contender.

But while the Titans, the NFL’s lone one-win team, appear to be speeding on their way to the top of the 2026 NFL draft, Tennessee has only lost its previous three games by a combined 16 points.

Titans rookie QB Cam Ward, the first overall pick in the NFL draft last April, has thrown for 2,220 yards, including 256 in last Sunday’s narrow loss to the Seahawks. Ward also threw and ran for a touchdown.

So, use caution in proceeding with any Jaguars-Titans betting slips as this spot amounts to a ‘Super Bowl’ for the home underdog Titans against an AFC South rival, while the Jaguars, naturally, may be peeking ahead a little bit.

But better overall play from QB Trever Lawrence, who threw three interceptions, in addition to losing a fumble that was returned for a touchdown, would go a long way in erasing any ideas of an upset loss in Tennessee.

Lawrence, 18-for-30 for 256 yards last week in Arizona, will have the services WR Brian Thomas Jr., returning from an ankle injury after missing the last two games, and WR Jakobi Meyers, acquired at the trade deadline from the Raiders, together for the first time this season. 

TE Brenton Strange, who in his return from a quad injury after missing five games had four receptions for 81 yards vs. the Cardinals last week, gives the Lawrence another reliable option.

But the Jaguars, just 2-2-1 against the spread on the road this season, have a big date looming next week, while the Titans are desperate to give their fans something to feel good about - right now.

And the sports books, agree, given the relatively low over/under total of 41.5 points 

(Please check out some of your favorite sports books right now for all updated NFL odds and betting information — as it is very important, that you shop around for the best prices and betting numbers you can find, in addition to always staying well-informed. And remember to bet responsibly and within your set budget.)