Unbeaten conference rivals clash in Gainesville as the surging Florida Gators look to stun Ole Miss.
The No. 21 Florida Gators are looking to start the year a perfect 4-0 (2-0) when No. 4 Ole Miss comes to town.
These two teams are a combined 6-0, with each winning their conference opener last weekend.
Florida hadn't won an SEC game the entire 2025 season, so to see them go to Auburn and take care of business was a huge boost to the confidence of head coach Jon Sumrall.
There's a feeling in the air that this team is different, and that's never been more apparent with the betting odds heading into this one.
Florida opened as the favorites, and that has remained the same even with it being just a few hours before kickoff.
Florida vs. Ole Miss betting odds
According to DraftKings, here are the latest betting odds:
- Spread: Ole Miss +3.5 (-110), Florida -3.5 (-110)
- Over/Under: Over 58.5 (-115), Under 58.5 (-105)
- Money Line: Ole Miss +142, Florida -170
To see Florida as the favorites is still a bit mind-blowing, but them playing at home is a huge advantage.
The Gators could pull off a top-five upset against the Rebels, and it's one that would change the entire perception of this team with Sumrall looking to lead them to a National Championship.
ESPN's matchup predictor
Similar to DraftKings, ESPN's matchup predictor also sees Florida coming out on top. According to ESPN Analytics, Florida has a 53.1% chance to win this game. The Rebels are still given a fair shot at 46.9%, and it makes sense that it's as close as it is due to the fact that the Gators are only favored by three and a half points.
ESPN's score prediction
Each and every week, ESPN's Bill Connelly updates his spreadsheet with an SP+ prediction for every FBS game.
Here in Week 4, he's predicting the Gators take home a 30-25 victory.
For those who trust Connelly's format, that would mean that taking the Gators spread or money line would be successful, in addition to betting the under as 55 points would fall just shy of the 58.5 it's currently set at, though there's still time for that to change before kickoff.
Can Florida pull off the upset?
Beating Auburn on the road is one thing, but taking down Ole Miss is another. This is a Rebels team that may be without their star running back, but that doesn't change the fact that they still have Trinidad Chambliss running the show.
Getting Eric Singleton back would be huge for the Gators, but would it be enough to knock off the Rebels?
