Struggling to find his rhythm in a new defensive scheme, the disruptive tackle must now anchor a vulnerable front against Baltimore's relentless, high-powered ground attack.
The status of Dallas Cowboys defensive tackle Quinnen Williams has been a main storyline this week as his place in new coordinator Christian Parker's defense has come under scrutiny.
With some thinking that Williams isn't suited to Parker's scheme, the Cowboys, naturally, rebuffed that notion, but there is no doubt Quinnen hasn't been the dominant force he was at stages last season.
But luckily, this week is perhaps the ideal time for Williams to remind everyone of what he can do.
With the Baltimore Ravens and Lamar Jackson up next in Rio, Williams will have a huge task: slowing down Lamar and Henry.
Given the Cowboys' struggles against running quarterbacks in the opening two weeks and the run defense in general, Quinnen revealed that it has been a huge emphasis for the group this week.
"We had a great learning experience the last game especially, and just definitely focus on it this week, learn from it, and definitely make [it] an emphasis," Williams said.
There's no other way to put it: Henry looms as the key to the game, and how the Cowboys' defensive line fares against Derrick will be a deciding factor in the game.
Of course, we can't forget about Lamar either, but Henry is the No. 1 player you simply have to stop if Dallas wants any hope of escaping Rio with a win.
And Williams - who might be a bit banged up, which could explain his relatively slow start - knows how important stifling the run will be against Baltimore.
"It's been challenging for us the whole season coming down, stopping run, especially [on the] interior," Williams said. "We just really focus on honing in the urgency level, being disruptive up front, playing with our hands, getting knocked back, and doing different things like that.
"So no matter who it is back there, we have to do our job up front to stop the run."
Washington and New York aren't known for being "elite" rushing teams, and the fact that both torched Dallas on the ground raises serious concerns about what an elite rushing attack like Baltimore's can do.
We also say "don't get beat by what you know," and the Cowboys know what is coming: a big dose of Henry and the Ravens' run game.
So, getting blown away by the rushing attack won't be a good look.
Dallas has had two great learning experiences going against rushing attacks in the opening fortnight ... but now comes its biggest test.
