RB Leipzig welcome PSV Eindhoven to the Red Bull Arena on Tuesday night for the second round of the Champions League league phase, with both sides looking to strengthen their European campaigns.

Leipzig suffered a heavy defeat against Como in their opening fixture, while PSV were held to a 1-1 draw by Shakhtar Donetsk after Sergiño Dest rescued a point with a second-half equaliser.

Martin Demichelis' side finished third in the Bundesliga last season and have made another solid domestic start, sitting fifth and only two points behind Bayern Munich.

Their overall form has been less convincing, with Leipzig losing three of their last five matches in all competitions. However, they go into Tuesday's game with significant confidence after a 6-0 victory over Frankfurt.

The Red Bull Arena has been a particularly strong base. Leipzig have won all three of their home matches this season, scoring 14 goals without conceding.

European consistency remains a concern, though. Leipzig have failed to keep a clean sheet in their last 19 UEFA club matches.

The German side have never previously faced PSV in a competitive fixture.

Peter Bosz's PSV sit second in the Eredivisie with 19 points from eight matches, one behind leaders Feyenoord. They have won six of their last seven games, although defensive concerns remain after conceding 10 league goals this season.

Their Champions League opener against Shakhtar showed both the strengths and weaknesses of their game. PSV fell behind before Dest's second-half equaliser earned a point.

Bosz must also manage a lengthy injury list. Adamo Nagalo is ruled out for the season, while Kiliann Sildillia and Alassane Pléa remain long-term absentees.

Paul Wanner and Ricardo Pepi are expected to return later this month, while Sam Lammers, Sami Ouaissa and Jerdy Schouten are also unavailable.

Matěj Kovář is expected to start in goal, with Sergiño Dest, Lutsharel Geertruida, Armando Obispo and Filip Kostić making up the back four.

Geertruida's return to Leipzig adds an intriguing subplot, with the defender facing his former club after joining PSV on loan from the Bundesliga side in August.

Leipzig are expected to line up with Maarten Vandevoordt behind Ridle Baku, Willi Orbán, Castello Lukeba and David Raum.

Neil El Aynaoui and Nicolas Seiwald should anchor midfield, allowing Christopher Nkunku to operate centrally behind the forward line. Nkunku has been directly involved in five goals across his last five Champions League starts for Leipzig and is the club's all-time leading player for goal involvements in the competition, with 16.

Antonio Nusa and Maksimović are expected to provide width around Brajan Gruda. Maksimović became Leipzig's youngest Champions League scorer against Como and could become the first player to score in each of his first two appearances for the club in the competition.

Guus Til, Kodai Sano and Noah Fernandez are expected to form PSV's midfield three, with Til arriving in strong scoring form.

Ivan Perišić and Ruben van Bommel should provide width around Sven Mijnans, who has been playing in a more advanced role since Ricardo Pepi's injury. Perišić remains an important source of experience and was the oldest outfield player to start on matchday one of this season's Champions League.

Predicted XI:

RB Leipzig: Vandevoordt; Baku, Orbán, Lukeba, Raum; El Aynaoui, Seiwald; Nusa, Nkunku, Maksimović; Gruda.

PSV: Kovář; Kostić, Obispo, Geertruida, Dest; Fernandez, Sano, Til; Van Bommel, Mijnans, Perišić.